Browsing Tag Managing Diabetes

The Food and Drug Administration (FDA) issued a warning a few years ago that pregnant women taking the selective serotonin reuptake inhibitor (SSRI) antidepressant paroxetine risk giving birth to infants with major birth defects, including heart abnormalities Now comes word that the same drug (sold as Paxil, Paxil CR, Seroxat, Pexeva, and generic paroxetine hydrochloride) carries another danger that could keep babies from being born in the first place. A new study just published in the online edition of the journal Fertility and Sterility concludes as many as fifty percent of all men taking the antidepressant could have damaged sperm and compromised fertility.

New York Presbyterian Hospital and Weill Cornell Medical Center researchers followed 35 healthy male volunteers who took paroxetine for five weeks. Then sperm samples from the men were studied using an assay called terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) to evaluate whether there were missing pieces of genetic code in the sperm DNA. This condition, know as DNA fragmentation, is associated with reproductive problems.

The results? The percentage of men with abnormal DNA fragmentation soared from less than 10 percent to 50 percent while taking the antidepressant. This is a crucial finding because DNA fragmentation has long been known to correlate with an increased risk of birth defects, poor fertility and unsuccessful pregnancy outcomes — even when high tech, extraordinarily expensive fertility enhancing techniques such as in vitro fertilization and intracytoplasmic sperm injection are used.

The study, one of the first scientific investigations into the effect of SSRIs on sperm quality, also confirmed that paroxetine impairs sexual function. More than a third of the research subjects reported significant changes in erectile function and about half had difficulty ejaculating.

“It’s fairly well known that SSRI antidepressants negatively impact erectile function and ejaculation. This study goes one step further, demonstrating that they can cause a major increase in genetic damage to sperm,” Dr. Peter Schlegel, the study’s senior author and chairman of the Department of Urology and professor of reproductive medicine at Weill Cornell Medical College, explained in a statement to the media. “Although this study doesn’t look directly at fertility, we can infer that as many as half of men taking SSRIs have a reduced ability to conceive. These men should talk with their physician about their treatment options, including non-SSRI depression medications.”

The scientists could not identify the exact way the SSRI caused the DNA fragmentation, but the evidence strongly suggests the drug slows sperm as it moves through the male reproductive tract from the testis to the ejaculatory ducts. When this happens, the sluggish sperm grows old and its DNA becomes damaged. “This is a new concept for how drugs can affect fertility and sperm. In most cases, it was previously assumed that a drug damaged sperm production, so the concept that sperm transport could be affected is novel,” Dr. Schlegel stated.

The study contains some good news for men currently on Paxil and related drugs who may be concerned about their fertility. All the changes the researchers found appeared to be totally reversible. Specifically, normal levels of sexual function and DNA fragmentation both returned to normal one month after discontinuation of the drug.

A higher dietary intake of omega-3 fatty acids may protect men from prostate cancer even if they have a genetic predisposition to the disease, researchers have found.

“We detected strong protective associations between increasing intake of long-chain omega-3 polyunsaturated fatty acids and more advanced prostate cancer,” said lead researcher John S. Witte. “These fatty acids are primarily from dark fish such as salmon.”

“And the decrease in risk may be even more pronounced if one has a high-risk genetic variant,” he said.

In a study published in the journal Clinical Cancer Research, Witte and colleagues compared the diets and genetic profiles of 466 men suffering from aggressive prostate cancer with those of 478 healthy men of similar age and ethnic distribution. Average participant age was 65, and cancer patients were recruited an average of 4.7 months after diagnosis. Healthy controls were recruited from among men undergoing standard annual health checkups.

The researchers focused only on aggressive tumors because these represent the most dangerous form of the disease. Many men with non-aggressive, slow-growing tumors die of other causes before ever experiencing any cancer symptoms.

Researchers had all participants fill out food frequency questionnaires, classifying their intake of various kinds of fish as “never,” “one to three times per month,” or “one or more times per week.” All men were screened for nine different mutations of the cox-2 gene. These variables were then analyzed for their relationship with prostate cancer, adjusting for other known risk factors such as smoking, obesity, family cancer history and prior prostate screening results.

The study was conducted by researchers from the Institute for Human Genetics, University of California and University of Southern California, and funded by the National Institute of Health and a dean’s grant from Laval University McLaughlin.

The researchers found that men with cancer had a significantly higher intake of calories, fat and linoleic acid (an omega-6) than healthy men. They had a significantly lower intake of omega-3s, shellfish and dark fish.

Men who ate dark fish one to three times a month had a 36 percent lower chance of developing an aggressive prostate cancer than those who ate it rarely or never, while those who ate such fish once a week or more had a 63 percent lower risk.

“The strongest effect was seen from eating dark fish such as salmon one or more times per week,” Witte said.

The researchers found that men with a particular cox-2 gene variant, rs4647310, had 5.5-times the risk of aggressive prostate cancer as men without that variant. This elevated risk was not seen, however, among men with a high omega-3 intake.

“Men with low intake of dark fish and the high-risk variant had a substantially increased risk of more advanced prostate cancer,” Witte said.

Omega-3s are believed to decrease the risk of cardiovascular disease, cancer, and autoimmune disorders, and to improve cognitive health. The mechanisms for these benefits are not well understood, but are believed, in some cases, to be linked to reduced inflammation.

The cox-2 gene is known to play a role in prostate inflammation, a risk factor for prostate cancer.

For many years, we have been doing a Natural Fertility Program for couples who are delighted with the results.

Be well

Dr Sundardas

http://www.naturaltherapies.com/nfp.htm

Diabetes management is something that many must deal with on a day to day basis. About 16 million Americans suffer from diabetes mellitus, a chronic disease in which the pancreas produces too little or no insulin, impairing the body’s ability to turn sugar into usable energy.

In recent years, the Food and Drug Administration has approved a fast-acting form of human insulin and several new oral diabetes drugs, including the most recent, Rezulin (troglitazone), the first of a new class of drugs called insulin sensitizers. This drug is designed to help Type II diabetics make better use of the insulin produced by their bodies and could help as many as 1 million Type II diabetics reduce or eliminate their need for insulin injections.

While it is treatable, diabetes is still a killer. Thus, diabetes management is extremely important. The fourth leading cause of death in America, diabetes claims an estimated 178,000 lives each year. So the treatment is aimed at holding the disease in check, reversing it where possible, and preventing complications.

Philip Cryer, M.D., a professor at Washington University School of Medicine in St. Louis and president of the American Diabetes Association, believes that most people simply don’t understand the magnitude of the diabetes problem. “Diabetes is an increasingly common, potentially devastating, treatable yet incurable, lifelong disease. It’s the leading cause of blindness in working-age adults, the most common cause of kidney failure leading to dialysis or transplants, and is a leading cause of amputation,” he says. “The most recent estimate we have of diabetes’ cost [in terms of] direct medical care is $90 billion dollars annually–more than heart disease, cancer, or AIDS.”

At the heart of diabetes control are dietary management and drug treatment. The increasing emphasis on the importance of a healthy diet, the availability of glucose monitoring devices that can help diabetics keep a close watch over blood sugar levels, and the wide range of drug treatments enable most diabetics to live a near-normal life.
Managing the diet is easier now because of food labeling regulations that went into effect in 1994 (see “The New Food Label: Coping with Diabetes” in the November 1994 FDA Consumer).According to the Corn Refiners Association, high-fructose corn syrup (HFCS) is no worse for you than any other dietary carbohydrate. Many health experts, however, disagree, warning consumers that HFCS is strongly correlated with diabetes and obesity.

According to NaturalNews, these quotes tell you how bad the problems is:

Roughly $40 billion in federal subsidies are going to pay corn growers, so that corn syrup is able to replace cane sugar. corn syrup has been singled out by many health experts as one of the chief culprits of rising obesity, because corn syrup does not turn off appetite. Since the advent of corn syrup, consumption of all sweeteners has soared, as have people’s weights. According to a 2004 study reported in the American journal of Clinical Nutrition, the rise of Type-2 diabetes since 1980 has closely paralleled the increased use of sweeteners, particularly corn syrup.
There is a Cure for Diabetes: The Tree of Life 21-Day+ Program by Gabriel Cousens

Since the fructose in corn syrup does neither stimulate insulin secretion nor reduce the hunger hormone ghrelin, you will continue to feel hungry while the body converts the fructose into fat. The resulting obesity increases the risk of diabetes and other diseases. Since you obviously cannot expect to receive much help from those who only know how to treat the effects of illness and not its causes, you may need to take your health into you own hands.
Timeless Secrets of Health & Rejuvenation: Unleash The Natural Healing Power That Lies Dormant Within You by Andreas Moritz

More than half of the carbohydrates being consumed are in the form of sugars (sucrose, corn syrup, etc.) being added to foods as sweetening agents. High consumption of refined sugars is linked to many chronic diseases, including obesity, diabetes, heart disease, and cancer. Generally, the term “dietary fiber” refers to the components of plant cell wall and non-nutritive residues. Originally, the definition was restricted to substances that are not digestible by the endogenous secretions of the human digestive tract.
Textbook of Natural Medicine 2nd Edition Volume 1 by Michael T. Murray, ND

The following are tips to prevent or manage diabetes (Type 2);

1) If you have a history of diabetes in your family, recognize you will have a higher tendency to do so. Very often diabetes is a disease of denial.

2) Watch your weight. DO not let it exceed more than 5% of your optimum body weight when you wer at your healthiest. Studies have shown that every 5% increase to correlate to a 200% risk of mature onset diabetes. (Weight gain and the Risk of Developong Insulin Resistance Syndrome . Everson SA, et al. Diabetes Care 1998;21(10):1637-43)

3) Exercise regularly and lifelong. Studies have shown, it helps to protect against diabetes.(The Protective Effect of Good Physical Fitness when young on the Risk of Impaired Glucose Tolerance when Old)Takemura Y, et al. Prev Med 1999;28(1):14-9 )

4) Watch your carbohydrates really carefully if you are at high risk. Use complex carbohydrates.
(Heterogeneity in associations between macronutrient intake and lipoprotein profile in individuals with type 2 diabetes) Mayer-Davis EJ;Levin S;Marshall JA, Diabetes care Oct 1999 22(10) p1632-9)

5) Follow the blood type diet. The lectins in food which are antagonistic to your blood cells can lead to pancreatic damage.

Be well
Dr Sundardas